Divisi Alergi Imunologi
Bagian/SMF Ilmu Kesehatan Anak FK-Unair/RSU Dr.Soetomo Surabaya
Pencegahan penyakit alergi pada trimester kehidupan bayi sangat penting dimulai dengan pencegahan alergi susu sapi, oleh karena sekali respons IgE dimulai, kaskade inflamasi alergi akan berlanjut pada usia bayi selanjutnya, dan sensitisasi terhadap alergen makanan lain dan aero-alergen akan terjadi.
Probiotik mempunyai peran yang unik dalam proses pencegahan penyakit alergi, selain menghambat pertumbuhan kuman lain, probiotik membangkitkan respons imun mukosa S-IgA. Secara sistemik membangkikan peranan T regulator yang akan menghambat aktifitas Th2 yang berlebihan, maupun aktifitas Th1 yang berlebihan.
Probiotik juga mengaktifkan respons imun non specifik (innate) dan spesific (adapted).
Abstract
Allergy prevention in the first trimester of infant age is very important especially to cow’s milk,
because once IgE response has been initiated, it progresses throughout the infant life, and sensitization to other food allergen and aero-allergen may develop.
Probiotic has a unique role in the prevention of allergic disease, instead of inhibitory to other patogen growth, probiotic also enhances the development of mucosal S-IgA response.
In the systemic immune response, probiotic enhances the development of regulatory T-cell which in turn will down-regulate the over-activity of Th2, and down-regulate the over activity of Th1.
Key words: Probiotic, prevention of allergy, IgE, S-IgA, T-regulatory, Th2, Th1
Probiotik mempunyai peran yang unik dalam proses pencegahan penyakit alergi, selain menghambat pertumbuhan kuman lain, probiotik membangkitkan respons imun mukosa S-IgA. Secara sistemik membangkikan peranan T regulator yang akan menghambat aktifitas Th2 yang berlebihan, maupun aktifitas Th1 yang berlebihan.
Probiotik juga mengaktifkan respons imun non specifik (innate) dan spesific (adapted).
Abstract
Allergy prevention in the first trimester of infant age is very important especially to cow’s milk,
because once IgE response has been initiated, it progresses throughout the infant life, and sensitization to other food allergen and aero-allergen may develop.
Probiotic has a unique role in the prevention of allergic disease, instead of inhibitory to other patogen growth, probiotic also enhances the development of mucosal S-IgA response.
In the systemic immune response, probiotic enhances the development of regulatory T-cell which in turn will down-regulate the over-activity of Th2, and down-regulate the over activity of Th1.
Key words: Probiotic, prevention of allergy, IgE, S-IgA, T-regulatory, Th2, Th1
